CERAMIDE TRANSFER PROTEIN DEFICIENCY COMPROMISES ORGANELLE FUNCTION AND LEADS TO SENESCENCE IN PRIMARY CELLS.

Ceramide transfer protein deficiency compromises organelle function and leads to senescence in primary cells.

Ceramide transfer protein (CERT) transfers ceramide from the endoplasmic reticulum (ER) to the Golgi complex.Its deficiency in mouse leads to embryonic death at E11.5.CERT deficient Quickstrikes embryos die from cardiac failure due to defective organogenesis, but not due to ceramide induced apoptotic or necrotic cell death.In the current study we e

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Maternal mRNA input of growth and stress-response-related genes in cichlids in relation to egg size and trophic specialization

Abstract Background Egg size represents an Herbal Teas important form of maternal effect determined by a complex interplay of long-term adaptation and short-term plasticity balancing egg size with brood size.Haplochromine cichlids are maternal mouthbrooders showing differential parental investment in different species, manifested in great variation

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Flor yeast: new perspectives beyond wine ageing

The most important dogma in white-wine production is the preservation of the wine aroma and the limitation of the oxidative action of oxygen.In contrast, the ageing of Sherry and Sherry-like wines is an aerobic process that depends on the Lifestyle oxidative activity of flor strains of Saccharomyces cerevisiae.Under depletion of nitrogen and fermen

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Body contouring following massive weight loss

Obesity is a global disease with epidemic proportions.Bariatric surgery or modified lifestyles go a long way in mitigating the vast weight gain.Patients following these interventions Paring Knives usually undergo massive weight loss.This results in redundant tissues in various parts of the body.Loose skin causes increased morbidity and psychologica

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